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Review: inflammatory response variables, descriptors of peritoneal irritation, and migration of pain are most discriminatory of appendicitis

Clinical impact ratings GP/FP/Primary care IM/Ambulatory care Internal Medicine Emergency medicine

Key Words: appendicitis • laboratory techniques and procedures

The first 150 words of the full text of this article appear below.

METHODS
Data sources: Medline (to June 1, 2003), bibliographies of relevant studies, and personal files.

Study selection and assessment: published studies on the clinical and laboratory diagnosis of appendicitis in patients admitted to hospital with suspected appendicitis. Results had to be presented so that likelihood ratios and areas under the receiver operating characteristic (ROC) curve could be calculated. Studies of children, patients with abdominal pain, patients having surgery, or comparisons of patients with verified appendicitis and healthy persons were not eligible.

Outcomes: ROC areas, and positive and negative likelihood ratios were used to describe the diagnostic performance of variables for diagnosing appendicitis.

MAIN RESULTS
24 studies (5833 patients) met the selection criteria, which described 28 diagnostic variables for diagnosing appendicitis in patients with suspected appendicitis. The proportion of patients with a diagnosis of appendicitis ranged from 27–61% (median 41%). In 23 studies, the diagnosis was confirmed by histopathological examination. Certain variables, including inflammatory . . . [Full text of this article]

Marcia Edmonds, MD

University of Alberta
Edmonton, Alberta, Canada