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Review: rotavirus vaccines moderately reduce rotavirus diarrhoea in children

Clinical impact ratings Paediatrics Tropical medicine Infectious disease

Key Words: diarrhoea • rotavirus infections • rotavirus vaccines

The first 150 words of the full text of this article appear below.

METHODS
Data sources: Cochrane Infectious Diseases Group’s trials register, Medline, EMBASE/Excerpta Medica, LILACS, Biological Abstracts (all up to October 2003), Cochrane Central Register of Controlled Trials (2003, Issue 3), bibliographies of relevant articles, and contact with researchers and a rotavirus manufacturer (Merck Sharp & Dohme).

Study selection and assessment: randomised controlled trials (RCTs) in any language that compared rotavirus vaccines with placebo, no vaccination, or a different rotavirus vaccine in children or adults. Study quality was assessed for method of allocation, allocation concealment, blinding, sample size, exclusions after randomisation, and follow up period.

Outcomes: rotavirus diarrhoea, all cause diarrhoea, all cause mortality, and adverse events.

MAIN RESULTS
63 RCTs of children (age range newborns to 12 years) and 1 small safety study of 10 adults (21–30 years of age) met the selection criteria. Main types of vaccines evaluated included bovine (13 RCTs), human (2 RCTs), rhesus (32 RCTs), and the combined bovine and . . . [Full text of this article]

John W L Puntis, BM (Hons), DM, FRCP, FRCPCH

The General Infirmary at Leeds, University of Leeds
Leeds, UK