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THERAPEUTICS
Tonstad S, Tonnesen P, Hajek P, et al. Effect of maintenance therapy with varenicline on smoking cessation: a randomized controlled trial. JAMA 2006;296:945.
GP/FP Primary care 





Public health 





Lander JA. Weltman BJ, So SS. EMLA and amethocaine for reduction of childrens pain associated with needle insertion. Cochrane Database Syst Rev 2006;(3):CD004236.[Medline]
GP/FP/Primary care 





Emergency medicine 





Paediatrics 





Paediatric hospital medicine 





Digiovanni BF, Nawoczenski DA, Malay DP, et al. Plantar fascia-specific stretching exercise improves outcomes in patients with chronic plantar fasciitis. A prospective clinical trial with two-year follow-up. J Bone Joint Surg Am 2006;88:177581.
GP/FP Primary care 





Physical medicine & rehabilitation 





Surgeryorthopaedics 





Kearon C, Ginsberg JS, Douketis J, et al. An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trial. Ann Intern Med 2006;144:81221.
GP/FP Primary care 





IM/Ambulatory care 





Emergency medicine 





Haematology 





Respirology 





Wright M, Grieve R, Roberts J, et al. Health benefits of antiviral therapy for mild chronic hepatitis C: randomised controlled trial and economic evaluation. Health Technol Assess 2006;10:1113.[Medline]
IM/Ambulatory care 





Infectious disease 





Gastroenterology 





Scharf HP, Mansmann U, Streitberger K, et al. Acupuncture and knee osteoarthritis: a three-armed randomized trial. Ann Intern Med 2006;145:1220.
GP/FP Primary care 





IM/Ambulatory care 





Rheumatology 





Wang C, Harris WS, Chung M, et al. N-3 fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Am J Clin Nutr 2006;84:517.
GP/FP Primary care 





IM/Ambulatory care 





Cardiology 





Smith RC, Lyles JS, Gardiner JC, et al. Primary care clinicians treat patients with medically unexplained symptoms: a randomized controlled trial. J Gen Intern Med 2006;21:6717.[CrossRef][Medline]
GP/FP Primary care 





GP/FP/Mental health 





Psychiatry 





Ferri M, Amato L, Davoli M. Alcoholics Anonymous and other 12-step programmes for alcohol dependence. Cochrane Database Syst Rev 2006;(3):CD005032.[Medline]
GP/FP Primary care 





GP/FP/Mental health 





Psychiatry 





Seehusen DA, Johnson DR, Earwood JS, et al. Improving womens experience during speculum examinations at routine gynaecological visits: randomised clinical trial. BMJ 2006;333:171.
GP/FP Primary care 





Gynaecology 





Barnard ND, Cohen J, Jenkins DJ, et al. A low-fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes. Diabetes Care 2006;29:177783.
GP/FP Primary care 





IM/Ambulatory care 





Christ-Crain M, Stolz D, Bingisser R, et al. Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial. Am J Respir Crit Care Med 2006;174:8493.
GP/FP Primary care 





Internal medicine 





Geriatrics 





Infectious disease 





Respirology 





Emergency medicine 





Cipriani A, Rendell JM, Geddes JR. Haloperidol alone or in combination for acute mania. Cochrane Database Syst Rev 2006;(3):CD004362.[Medline]
GP/FP/Mental health 





Psychiatry 





Nedrow A, Miller J, Walker M, et al. Complementary and alternative therapies for the management of menopause-related symptoms: a systematic evidence review. Arch Intern Med 2006;166:145365.
GP/FP Primary care 





Gynaecology 





Allen LA, Woolfolk RL, Escobar JI, et al. Cognitive-behavioral therapy for somatization disorder: a randomized controlled trial. Arch Intern Med 2006;166:15128.
GP/FP Primary care 





GP/FP/Mental health 





Psychiatry 





Schuh S, Dick PT, Stephens D, et al. High-dose inhaled fluticasone does not replace oral prednisolone in children with mild to moderate acute asthma. Pediatrics 2006;118:64450.
GP/FP/Primary care 





Respirology 





Paediatrics 





Dickinson HO, Nicolson DJ, Campbell F, et al. Magnesium supplementation for the management of essential hypertension in adults. Cochrane Database Syst Rev 2006;(3):CD004640.[Medline]
GP/FP Primary care 





IM/Ambulatory care 





Eisenberg E, McNicol E, Carr DB. Opioids for neuropathic pain. Cochrane Database Syst Rev 2006;(3):CD006146.[Medline]
GP/FP Primary care 





IM/Ambulatory care 





Neurology 





Macdonald JK, McDonald JW. Natalizumab for induction of remission in Crohns disease. Cochrane Database Syst Rev 2006;(3):CD006097.[Medline]
Gastroenterology 





Mytton J, DiGuiseppi C, Gough D, et al. School-based secondary prevention programmes for preventing violence. Cochrane Database Syst Rev 2006;(3):CD004606.[Medline]
GP/FP/Primary care 





Public health 





Clark DM, Ehlers A, Hackmann A, et al. Cognitive therapy versus exposure and applied relaxation in social phobia: a randomized controlled trial. J Consult Clin Psychol 2006;74:56878.[CrossRef][Medline]
Psychiatry 





GP/FP/Mental health 





Conterno LO, Silva Filho CR, Ruggeberg JU, et al. Conjugate vaccines for preventing meningococcal C meningitis and septicaemia.Cochrane Database Syst Rev 20061;(3):CD001834.[Medline]
GP/FP Primary care 





IM/Ambulatory care 





Infectious disease 





Paediatrics 





Dahl R, Kapp A, Colombo G, et al. Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 2006;118:43440.[CrossRef][Medline]
GP/FP Primary care 





Allergy & immunology 





Paediatrics 





Goldfield GS, Mallory R, Parker T, et al. Effects of open-loop feedback on physical activity and television viewing in overweight and obese children: a randomized, controlled trial. Pediatrics 2006;118:e15766.
GP/FP/Primary care 





Paediatrics 





Public health 





McMillan-Price J, Petocz P, Atkinson F, et al. Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: a randomized controlled trial. Arch Intern Med. 2006;166:146675.
GP/FP Primary care 





Endocrine 





Giombini A, Di Cesare A, Safran MR, et al. Short-term effectiveness of hyperthermia for supraspinatus tendinopathy in athletes: a short-term randomized controlled study. Am J Sports Med 2006;34:124753.
GP/FP Primary care 





Physcial medicine & rehabilitation 





Surgeryorthopaedics 





Denis C, Fatseas M, Lavie E, et al. Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings. Cochrane Database Syst Rev 2006;(3):CD005194.[Medline]
GP/FP Primary care 





Psychiatry 





Dickinson HO, Nicolson DJ, Campbell F, et al. Potassium supplementation for the management of primary hypertension in adults. Cochrane Database Syst Rev 2006;(3):CD004641.[Medline]
GP/FP Primary care 





IM/Ambulatory care 





DIAGNOSIS
Rana R, Vlahakis NE, Daniels CE, et al. B-type natriuretic peptide in the assessment of acute lung injury and cardiogenic pulmonary edema. Crit Care Med 2006;34:19416.[CrossRef][Medline]
Internal medicine 





Cardiology 





Critical care 





Uzzan B, Cohen R, Nicolas P, et al. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med 2006;34:19962003.[CrossRef][Medline]
Internal medicine 





Infectious disease 





Critical care 





Nemec G, Ventura A, Stefano M, et al. Looking for celiac disease: diagnostic accuracy of two rapid commercial assays. Am J Gastroenterol 2006l;101:1597600.[CrossRef][Medline]
GP/FP Primary care 





IM/Ambulatory care 





Little P, Turner S, Rumsby K, et al. Developing clinical rules to predict urinary tract infection in primary care settings: sensitivity and specificity of near patient tests (dipsticks) and clinical scores. Br J Gen Pract 2006;56:60612.[Medline]
GP/FP Primary care 





Emergency medicine 





Surgerygeneral 





PROGNOSIS
Tonelli M, Wiebe N, Culleton B, et al. Chronic kidney disease and mortality risk: a systematic review. J Am Soc Nephrol 2006;17:203447.
GP/FP Primary care 





IM/Ambulatory care 





Nephrology 





Cardiology 





Endocrine 





McRae S, Tran H, Schulman S, et al. Effect of patients sex on risk of recurrent venous thromboembolism: a meta-analysis. Lancet 2006;368:3718.[CrossRef][Medline]
GP/FP Primary care 





IM/Ambulatory care 





Haematology 





AETIOLOGY
Shankar A, Klein R, Klein BE. The association among smoking, heavy drinking, and chronic kidney disease. Am J Epidemiol 2006;164:26371.
GP/FP Primary care 





Nephrology 





Diehm C, Lange S, Darius H, et al. Association of low ankle brachial index with high mortality in primary care. Eur Heart J 2006;27:17439.
GP/FP Primary care 





Cardiology 





Geriatrics 





Villeneuve PJ, Holowaty EJ, Brisson J, et al. Mortality among Canadian women with cosmetic breast implants. Am J Epidemiol 2006;164:33441.
GP/FP Primary care 





Surgeryplastic 





QUALITY IMPROVEMENT
Shojania KG, Ranji SR, McDonald KM, et al. Effects of quality improvement strategies for type 2 diabetes on glycemic control: a meta-regression analysis. JAMA 2006;296:42740.
GP/FP Primary care 





IM/Ambulatory care 





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