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THERAPEUTICS
Pimentel M, Park S, Mirocha J, et al. The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial. Ann Intern Med 2006;145:55763.
Gastroenterology 





Raymond EG, Stewart F, Weaver M, et al. Impact of increased access to emergency contraceptive pills: a randomized controlled trial. Obstet Gynecol 2006;108:1098106.
GP/FP/Primary care 





Gynaecology 





Richter B, Bandeira-Echtler E, Bergerhoff K, et al. Pioglitazone for type 2 diabetes mellitus.Cochrane Database Syst Rev 2006;(4):CD006060.
GP/FP/Primary care 





IM/Ambulatory care 





Cardiology 





Endocrine 





Gardner F, Burton J, Klimes I, et al. Randomised controlled trial of a parenting intervention in the voluntary sector for reducing child conduct problems: outcomes and mechanisms of change. J Child Psychol Psychiatry 2006;47:112332.[CrossRef][Medline]
GP/FP/Primary care 





Paediatrics 





Psychiatry 





GP/FP/Mental health 





Etter JF. Cytisine for smoking cessation: a literature review and a meta-analysis.Arch Intern Med 2006;166:15539.
GP/FP Primary care 





Respirology 





Public health 





Bellieni CV, Cordelli DM, Raffaelli M, et al. Analgesic effect of watching TV during venipuncture. Arch Dis Child 2006;91:10157.
GP/FP/Primary care 





Paediatrics 





Fossey J, Ballard C, Juszczak E, et al. Effect of enhanced psychosocial care on antipsychotic use in nursing home residents with severe dementia: cluster randomised trial. BMJ 2006;332:75661.
GP/FP/Primary care 





Psychiatry 





Geriatrics 





Neurology 





Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006;355:141931.
IM/Ambulatory care 





Surgeryophthalmology 





Geriatrics 





SPACE Collabroative Group; Ringleb PA, Allenberg J, Bruckmann H, et al. 30 day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a randomised non-inferiority trial. Lancet 2006;368:123947.[CrossRef][Medline]
IM/Ambulatory care 





Neurology 





Surgeryneurosurgery 





Surgeryvascular 





Ziegler D, Ometov A, Dyck, PJ, et al. Oral treatment with
-lipoic acid improves symptomatic diabetic polyneuropathy Diabetes Care 2006;28:2365.
IM/Ambulatory care 





Endocrine 





Neurology 





Chou R, Fu R, Huffman LH, et al. Initial highly-active antiretroviral therapy with a protease inhibitor versus a non-nucleoside reverse transcriptase inhibitor: discrepancies between direct and indirect meta-analyses. Lancet 2006;368:150315.[CrossRef][Medline]
IM/Ambulatory care 





Infectious disease 





Hulten E, Jackson JL, Douglas K, et al. The effect of early, intensive statin therapy on acute coronary syndrome: a meta-analysis of randomized controlled trials. Arch Intern Med 2006;166:181421.
Internal Medicine 





Cardiology 





Ebbens FA, Scadding GK, Badia L, et al. Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol 2006;118:114956.[CrossRef][Medline]
Allergy/Immunology 





Infectious disease 





Kacmarek RM, Wiedemann HP, Lavin PT, et al. Partial liquid ventilation in adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2006;173:8829.
Respirology 





Intensivist 





Dechelotte P, Hasselmann M, Cynober L, et al. L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. Crit Care Med 2006;34:598604.[CrossRef][Medline]
Endocrine 





Infectious disease 





Gastroenterology 





Intensivist 





Grosse SD, Rosenfeld M, Devine OJ, et al. Potential impact of newborn screening for cystic fibrosis on child survival: a systematic review and analysis. J Pediatr 2006;149:3626.[CrossRef][Medline]
Paediatrics 





Djokomuljanto S, Quah BS, Surini Y, et al. Efficacy of phototherapy for neonatal jaundice is increased by the use of low-cost white reflecting curtains. Arch Dis Child Fetal Neonatal Ed 2006;91:F43942.
Paediatrics 





Egol KA, Paksima N,Puopolo S, et al. Treatment of external fixation pins about the wrist: a prospective, randomized trial. J Bone Joint Surg Am 2006;88:954.
Surgeryorthopaedics 





Osman I, MacKenzie F, Norrie J, et al. The "PRIM" study: a randomized comparison of prostaglandin E2 gel with the nitric oxide donor isosorbide mononitrate for cervical ripening before the induction of labor at term. Am J Obstet Gynecol 2006;194:101221.[CrossRef][Medline]
Obstetrics 





Nunes FP, Campos AP, Pedroso SR, et al. Intravaginal glyceryl trinitrate and dinoprostone for cervical ripening and induction of labor. Am J Obstet Gynecol 2006;194:10226.[CrossRef][Medline]
Obstetrics 





Moreland EC, Volkening LK, Lawlor MT, et al. Use of a blood glucose monitoring manual to enhance monitoring adherence in adults with diabetes: a randomized controlled trial. Arch Intern Med 2006;166:68995.
GP/FP/Primary care 





Endocrine 





Szajewska H, Ruszczynski M, Radzikowski A. Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials. J Ped 2006;149:367372.[CrossRef][Medline]
GP/FP/Primary care 





Paediatrics 





Infectious disease 





Soria R, Legido A, Escolano C, et al. A randomised controlled trial of motivational interviewing for smoking cessation. Br J Gen Pract 2006;56:76874.[Medline]
GP/FP Primary care 





Reilly JJ, Kelly L, Montgomery C, et al. Physical activity to prevent obesity in young children: cluster randomised controlled trial. BMJ 2006;333:1041.
GP/FP/Primary care 





Public health 





Paediatrics 





Obesityphysician 





Damen L, Bruin J, Koes BW, et al. Prophylactic treatment of migraine in children. Part 1. A systematic review of non-pharmacological trials. Cephalagia 2006;26:37383.[CrossRef][Medline]
GP/FP/Primary care 





Neurology 





Paediatrics 





Connock M, Frew E, Evans BW, et al. The clinical effectiveness and cost-effectiveness of newer drugs for children with epilepsy. A systematic review. Health Technol Assess 2006;10:iiiiv,ix118.[Medline]
GP/FP/Primary care 





Paediatrics 





Neurology 





Curioni C, Andre C. Rimonabant for overweight or obesity. Cochrane Database Syst Rev 2006;(4):CD006162.
GP/FP/Primary care 





Endocrine 





Obesityphysician 





Nair KS, Rizza RA, OBrien P, et al. DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med 2006;355:164759.
IM/Ambulatory care 





Endocrine 





Geriatrics 





Lavi R, Yernitzky D, Rowe JM, et al. Standard vs atraumatic Whitacre needle for diagnostic lumbar puncture: a randomized trial. Neurology 2006;67:14924.
Emergency medicine 





Internal medicine 





Safdar B, Degutis LC, Landry K, et al. Intravenous morphine plus ketorolac is superior to either drug alone for treatment of acute renal colic. Ann Emerg Med 2006;48:17381[CrossRef][Medline]
Emergency medicine 





Nephrology 





Hutton EF, Hofmeyr GJ. External cephalic version for breech presentation before term. Cochrane Database Syst Rev 2006;(1):CD000084.
Obstetrics 





DIAGNOSIS
Geva A, Bornstein J, Dan M, et al. The VI-SENSE-vaginal discharge self-test to facilitate management of vaginal symptoms. Am J Obstet Gynecol 2006;195:13516.[Medline]
GP/FP/Primary care 





Infectious disease 





Gynaecology 





PROGNOSIS
Newton JD, Squire IB. Glucose and haemoglobin in the assessment of prognosis after first hospitalisation for heart failure. Heart 2006;92:14416.
Internal medicine 





Cardiology 





Endocrine 





AETIOLOGY
Zhu JL, Basso O, Obel C, et al. Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. BMJ 2006;333:679.
Gynaecology 





GP/FP/Obstetrics 





Obstetrics 





Willum-Hansen T, Staessen JA, Torp-Pedersen C, et al. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation 2006;113:66470.
GP/FP Primary care 





IM/Ambulatory care 





Cardiology 





Latthe P, Mignini L, Gray R, et al. Factors predisposing women to chronic pelvic pain: systematic review. BMJ 2006;332:74955.
GP/FP Primary care 





Gynaecology 





Osler M, Nordentoft M, Andersen AM. Childhood social environment and risk of drug and alcohol abuse in a cohort of Danish men born in 1953. Am J Epidemol 2006;163:65461.
GP/FP/Primary care 





Public health 





Psychiatry 





QUALITY IMPROVEMENT
Coleman EA, Parry C, Chalmers S, et al. The care transitions intervention: results of a randomized controlled trial. Arch Intern Med 2006;166:18228.
Internal medicine 





CLINICAL PREDICTION GUIDE
Henry MJ, Pasco JA, Sanders KM, et al. Fracture Risk (FRISK) Score: Geelong Osteoporosis Study. Radiology 2006;241:1906.
GP/FP Primary care 





IM/Ambulatory Care 





Geriatrics 





Rheumatology 





Surgeryorthopaedics 





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