THERAPEUTICS

Antihypertensive therapy with indapamide and perindopril reduced mortality in patients 80 years

N S Beckett

Dr N S Beckett, Imperial College, London, UK; n.beckett{at}imperial.ac.uk

STUDY DESIGN

TOP STUDY DESIGN STUDY QUESTION MAIN RESULTS CONCLUSION ABSTRACTED FROM REFERENCES

randomised placebo controlled trial (Hypertension in the Very Elderly Trial [HYVET]).

{concealed}*.

blinded (patients, clinicians, and outcome adjudication committee).

STUDY QUESTION

TOP STUDY DESIGN STUDY QUESTION MAIN RESULTS CONCLUSION ABSTRACTED FROM REFERENCES

195 centres in Europe, China, Australasia, and Tunisia.

3845 patients 80 years of age (mean age 84 y, 60% women) with persistent hypertension (mean sitting blood pressure [BP] 173/91 mm Hg). Exclusion criteria included accelerated or secondary hypertension, haemorrhagic stroke in the past 6 months, heart failure, gout, and dementia.

sustained-release indapamide, 1.5 mg/day, with perindopril, 2 or 4 mg/day, added if needed to reach targets of systolic BP <150 mm Hg and diastolic BP <80 mm Hg (n = 1933) or placebo (n = 1912).

stroke, heart failure, any cardiovascular event, and death from any cause, cardiovascular cause, cardiac cause, or stroke.

median 1.8 years.

99.6% (intention-to-treat analysis).

MAIN RESULTS

TOP STUDY DESIGN STUDY QUESTION MAIN RESULTS CONCLUSION ABSTRACTED FROM REFERENCES

Antihypertensive treatment reduced risks of heart failure, any cardiovascular event, and death from stroke or any cause (table). At 2 years, target BP was achieved by 48% of the antihypertensive treatment group and 20% of the placebo group.

CONCLUSION

TOP STUDY DESIGN STUDY QUESTION MAIN RESULTS CONCLUSION ABSTRACTED FROM REFERENCES

In patients 80 years of age with persistent hypertension, antihypertensive therapy with indapamide and perindopril reduced all-cause mortality.

*Bulpitt C, Fletcher A, Beckett N, et al. Drugs Aging 2001;18:151–64.

See glossary.

Abstract and commentary also appear in "ACP Journal Club: The Best Evidence for Patient Care" in Annals of Internal Medicine.

ABSTRACTED FROM

TOP STUDY DESIGN STUDY QUESTION MAIN RESULTS CONCLUSION ABSTRACTED FROM REFERENCES

Beckett NS, Peters R, Fletcher AE, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med 2008;358:1887–98.

Clinical Impact Ratings: Cardiology 7/7; GP/FP/Primary care 6/7; IM/Ambulatory care 6/7; Geriatrics 6/7

View this table: in this window | in a new window   Antihypertensive therapy v placebo in patients 80 years of age with persistent hypertension*

 

FOOTNOTES

Source of funding: British Heart Foundation and Institut de Recherches Internationales Servier.

---

 

Commentary

William W Hung, Rosanne M Leipzig

Mount Sinai Medical Center, New York, New York, USA

Commentary Therapeutics

HYVET found that antihypertensive treatment in the very old decreased mortality and the incidence of heart failure, with benefits seen within the first year. Although the reduction in some outcomes did not reach statistical significance, perhaps because the trial was stopped early, the results are impressive.

An earlier meta-analysis of randomised trials on the same topic found a decrease in stroke but not mortality.¹ The HYVET authors speculated that the discrepancy in mortality results may be related to differences in treatment regimens, particularly the use of an angiotensin-converting enzyme inhibitor rather than a β-blocker. The finding of a mortality benefit needs to be replicated.

Of note, the target BP in HYVET and the trials included in the INDANA meta-analysis¹ was higher than that recommended by current treatment guidelines.² This disparity raises the question of whether additional value would be provided in this age group by further lowering BP beyond the target pressure of 150/80 mm Hg, especially considering that this approach may increase adverse effects.

An important question about HYVET is whether the results are generalisable to most elderly people. The study sample was a relatively healthy group with low prevalence of diabetes mellitus and coronary artery disease. Patients with heart failure or dementia and those requiring nursing care were excluded. The relative benefits and risks of treating frail elderly people with multiple comorbid conditions were not addressed by this trial and may never be known. However, because heart failure is the most common reason for hospital admission in this population and strokes can be life-altering events even to the very frail, antihypertensive treatment in moderation may be the best way to prevent these outcomes. Being 80 years of age or older should not preclude antihypertensive treatment.

REFERENCES

TOP STUDY DESIGN STUDY QUESTION MAIN RESULTS CONCLUSION ABSTRACTED FROM REFERENCES

1. Gueyffier F, Bulpitt C, Boissel JP, et al.. Antihypertensive drugs in very old people: a subgroup meta-analysis of randomised controlled trials. INDANA Group. Lancet 1999;353:793–6.[CrossRef][Medline]

2. Chobanian AV, Bakris GL, Black HR. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003;42:1206–52.[Abstract/Free Full Text]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?