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Therapeutics
A once yearly IV infusion of zoledronic acid prevented fractures in postmenopausal women with osteoporosis

https://doi.org/10.1136/ebm.12.5.145

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    Black DM, Delmas PD, Eastell R, et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 2007;356:1809–22.
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 Q In postmenopausal women with osteoporosis, does a once yearly intravenous infusion of zoledronic acid reduce the incidence of fractures?

    Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★★ Rheumatology ★★★★★★★ Endocrine ★★★★★★☆ Geriatrics ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised placebo controlled trial (Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly [HORIZON]).

    Embedded ImageAllocation:

    not concealed.*

    Embedded ImageBlinding:

    blinded (outcome assessors).*

    Embedded ImageFollow-up period:

    36 months.

    Embedded ImageSetting:

    clinics in 25 countries in Europe, North and Latin America, Australia, and Asia.

    Embedded ImagePatients:

    7765 postmenopausal women (mean age 73 y) with a bone mineral density T score ⩽2.5 at the femoral neck, with or without vertebral fractures, or with a T score ⩽1.5 and ⩾2 mild or 1 moderate vertebral fractures. Women were grouped as stratum 1 (n = 6113) if they were not taking …

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    Footnotes

    • ↵* See glossary.

    • For correspondence: Dr D M Black, University of California, San Francisco, CA, USA. dblack{at}psg.ucsf.edu

    • Source of funding: Novartis Pharma.

    Linked Articles

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2007; 12 160-160 Published Online First: 01 Oct 2007. doi: 10.1136/ebm.12.5.160