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Antenatal infection screening reduced preterm delivery
  1. Honest Honest, MD,
  2. Khalid S Khan, MD
  1. Birmingham Women’s Hospital,
 Birmingham, UK.

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 Q In pregnant women, does an antenatal programme of screening and treating vaginal infections reduce the rate of preterm delivery?

    Clinical impact ratings GP/FP/Obstetrics ★★★★★★☆ Obstetrics ★★★★★★☆ Infectious disease ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    {concealed*}.

    Embedded ImageBlinding:

    blinded {participants and healthcare providers}.*

    Embedded ImageFollow up period:

    to delivery or miscarriage.

    Embedded ImageSetting:

    25 non-hospital based antenatal clinics in Vienna, Austria.

    Embedded ImageParticipants:

    4429 pregnant women (mean age 29 y) presenting for their routine prenatal visit early in the second trimester without subjective complaints. All women were screened by Gram stain for asymptomatic vaginal infection, which was classified as bacterial vaginosis (BV), vaginal candidiasis, and Trichomonas vaginalis infection.

    Embedded ImageIntervention:

    infection screening programme (n = 2201) or control (n = 2228). For the infection screening programme, women and their obstetricians received the vaginal smear test results; women who were found to have vaginal infection received standard treatment within 7–10 days of diagnosis and obstetricians did follow up vaginal smears. For the control group, vaginal smear test results were not revealed to the women or their obstetricians so that the women’s standard antenatal care programme was not influenced.

    Embedded ImageOutcomes:

    spontaneous preterm delivery (delivery at <37 wk gestation). Secondary outcomes were preterm delivery at <37 weeks gestation combined with infant birth weight ⩽2500 g, and late miscarriages.

    Embedded ImagePatient follow up:

    94% (4155 women). Analysis was by intention to treat.

    MAIN RESULTS

    The infection screening programme group had lower rates of spontaneous preterm delivery and preterm delivery combined with infant birth weight ⩽2500 g than the control group (table). The 2 groups did not differ for rates of late miscarriages (table).

    Infection screening programme (ISP) v control in pregnant women*

    CONCLUSION

    In pregnant women, an antenatal programme of screening and treating vaginal infections reduced the rate of preterm delivery at <37 weeks gestation but not the rate of late miscarriages.

    Commentary

    Preterm birth accounts for a large proportion of neonatal and infant mortality and morbidity worldwide.1 Screening women who are asymptomatic for risk factors, infection, inflammatory markers, and cervical length early in pregnancy may provide an opportunity to optimise care and prevent prematurity and its complications. Research on the value of screening for asymptomatic vaginal infection is not conclusive, which results in considerable variation in practice. Whereas asymptomatic Candidiasis is often ignored, BV may be sought and treated, even though tests for BV have been found to be inaccurate in predicting spontaneous preterm birth.2

    The randomised trial by Kiss et al informs us that screening for BV, Trichomonas vaginalis, and Candida between 15 and 20 weeks’ gestation in women who are asymptomatic and treating these infections reduces spontaneous preterm birth before 37 weeks’ gestation, but not late miscarriages. However, spontaneous birth before 34 (not 37) weeks’ gestation is the pertinent outcome associated with complications of prematurity. Because information on this key outcome is lacking, it is difficult to be confident about the clinical significance of the findings. If clinicians convince themselves that screening and treating infections is worthwhile, as purported in the paper, they must realise that the authors diagnosed BV using grade 3 (presumably equivalent to Nugent score of 9 to 10)3 to indicate abnormal results. This represents an extreme end of the spectrum where women have marked presence of anaerobes and virtual absence of Lactobacillus species and may be virtually symptomatic (malodorous vaginal discharge). In other screening studies, a Nugent score ⩾7 is considered abnormal. In light of the lack of information on a clinically pertinent outcome and the uncertainty that exists in related literature, we are inclined to await further robust evidence with relevant outcome measures before embarking on a screening programme for asymptomatic women.

    References

    View Abstract

    Footnotes

    • * See glossary.

    • Information provided by author.

    • For correspondence: Dr H Kiss, University of Vienna Medical School, Vienna, Austria. herbert.kissmeduniwien.ac.at

    • Sources of funding: Fonds Gesundes Österreich and Federal Ministry of Education, Science, and Culture.

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