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Therapeutics
Prophylactic use of LMWH plus intermittent pneumatic compression prevented DVT in hip or knee arthroplasty

https://doi.org/10.1136/ebm.10.2.48

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    Silbersack Y, Taute BM, Hein W, et al. Prevention of deep-vein thrombosis after total hip and knee replacement. Low-molecular-weight heparin in combination with intermittent pneumatic compression. J Bone Joint Surg Br 2004;86:809–12.

    
 
 Q In patients receiving primary unilateral total hip or total knee replacement surgery, is prophylactic use of low molecular weight heparin (LMWH) plus intermittent pneumatic compression more effective than LMWH plus graduated compression stockings for reducing deep venous thrombosis (DVT)?

    Clinical impact ratings IM/Ambulatory care ★★★★★★☆ Internal medicine ★★★★★★☆ Surgery ★★★★★☆☆ Haematology ★★★★☆☆☆

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    {concealed*}†.

    Embedded ImageBlinding:

    unblinded.*

    Embedded ImageFollow up period:

    6–12 weeks

    Embedded ImageSetting:

    a university hospital in Germany

    Embedded ImagePatients:

    139 patients ⩾18 years of age who were awaiting primary unilateral total hip or knee replacement. Exclusion criteria included a history of cardiac insufficiency and chronic renal insufficiency.

    Embedded ImageIntervention:

    thromboembolic prophylaxis with LMWH plus intermittent pneumatic compression (n = 70) or LMWH plus graduated compression stockings (class 1, …

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    Footnotes

    • ↵* See glossary.

    • ↵† Information provided by author.

    • ↵* Information provided by author.

    • For correspondence: Dr Y Silbersack, Martin Luther University, Halle/Salle, Germany

    • Source of funding: Aircast Europa GmbH.

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      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2005; 10 64-64 Published Online First: 30 Mar 2005. doi: 10.1136/ebm.10.2.64