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Q In postmenopausal women with symptoms suggestive of overactive bladder (OAB) (urge or stress incontinence), does oestrogen therapy reduce symptoms more than placebo?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Gynaecology ★★★★★☆☆
METHODS
Data sources:
studies were identified by searching Medline, EMBASE/Excerpta Medica, Science Citation Index (January 1969 to December 1999), and reference lists of articles; and hand searching urology, gynaecology, gerontology, and primary care medicine journals.
Study selection and assessment:
studies in any language were selected if they were randomised controlled trials (RCTs) that were published or presented at a scientific meeting, reported symptoms suggestive of OAB (including frequency, urgency, or urge incontinence), and compared oestrogen with placebo.
Outcomes:
diurnal frequency, nocturnal frequency, incontinence episodes, urgency, first sensation to void, and bladder capacity. …
Footnotes
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For correspondence: Dr L Cardozo, King’s College Hospital, London, UK. lcardozocompuserve.com
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Source of funding: Pharmacia Corporation.