Haemoglobin A1c concentrations were associated with increased cardiovascular disease and all cause mortality
Q What is the relation between haemoglobin (Hb) A1c concentrations and coronary heart disease (CHD) events, cardiovascular disease (CVD) events, and all cause mortality?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★☆☆ Cardiology ★★★★★★☆ Endocrine ★★★★★☆☆
METHODS
Design:
cohort study (European Prospective Investigation into Cancer in Norfolk [EPIC-Norfolk]) with a mean follow up of 6 years.
Setting:
Norfolk, UK.
Patients:
10 232 patients 45–79 years of age (54% women, 2.4% with diabetes) who were recruited from general practice registers and had baseline data on a health and lifestyle questionnaire and HbA1c concentrations.
Risk factors:
HbA1c concentrations, known diabetes, age, body mass index, waist-to-hip ratio, systolic blood pressure, cholesterol concentrations, triglyceride concentrations, cigarette smoking, and history of heart attack or stroke.
Outcomes:
CHD events (hospital admission or death from CHD), CVD events (hospital admission …
