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Evid Based Med 10:89 doi:10.1136/ebm.10.3.89
  • Diagnosis

Review: a low clinical probability plus a normal D-dimer test result excludes a diagnosis of deep venous thrombosis

Rapid D-dimer testing combined with estimation of clinical probability for excluding a diagnosis of DVT*

D-dimer test result Estimated clinical probability 3 month cumulative incidence of DVT (95% CI)
*DVT  =  deep venous thrombosis; CI defined in glossary.
Normal on the SimpliRED D-dimer test Low 0.5% (0.07 to 1.1)
Moderate 3.5% (1.4 to 6.9)
High 21.4% (8.5 to 38)
Normal on the highly sensitive D-dimer tests Low or moderate 0.4% (0.04 to 1.1)
High 6.4% (1.7 to 15)

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