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Q In patients with non-diabetic nephropathy and persistent proteinuria, is an intensified blood pressure (BP) control programme more effective than conventional BP control for slowing progression to end stage renal disease (ESRD)?
Clinical impact ratings Nephrology ★★★★★★★
METHODS
Design:
randomised controlled trial (Ramipril Efficacy In Nephropathy [REIN] 2 trial).
Allocation:
concealed.*
Blinding:
unblinded.*
Follow up period:
median 19 months (total follow up period 36 mo).
Setting:
29 centres in Bulgaria, Italy, Spain, and Switzerland.
Patients:
338 patients (age range 18–70 years) with non-diabetic nephropathy and persistent proteinuria (ie, a proteinuria of 1–3 g/d and creatinine clearance <45 ml/min per 1.73 m2, or proteinuria ⩾3 g/d and creatinine clearance <70 ml/min per 1.73 m2) who had not received angiotensin converting enzyme (ACE) inhibition treatment for ⩾6 weeks. Exclusion criteria …
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