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Diagnosis
BNP and amino terminal proBNP assays did not differ for detecting congestive heart failure in the emergency department

https://doi.org/10.1136/ebm.10.5.148

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    Mueller T, Gegenhuber A, Poelz W, et al. Diagnostic accuracy of B type natriuretic peptide and amino terminal proBNP in the emergency diagnosis of heart failure. Heart 2005;91:606–12.
    OpenUrlAbstract/FREE Full Text

    
 
 Q In emergency department (ED) patients with dyspnoea, how do B type natriuretic peptide (BNP) concentrations compare with amino terminal proBNP (NT-proBNP) concentrations for detecting congestive heart failure (CHF)?

    Clinical impact ratings Internal medicine ★★★★★★★ Emergency medicine ★★★★★☆☆ Cardiology ★★★★★★☆

    METHODS

    Embedded ImageDesign:

    blinded comparison of BNP and NT-proBNP concentrations with a comfirmatory diagnosis of CHF based on the Framingham criteria after reviewing patient medical records.

    Embedded ImageSetting:

    a hospital in Linz, Austria.

    Embedded ImagePatients:

    251 ED patients (mean age 73 y, 93% men) who had shortness of breath as the most prominent symptom. Patients with acute coronary syndromes were excluded.

    Embedded ImageDescription of tests:

    BNP and NT-proBNT concentrations in plasma were measured by the AxSYM BNP assay (Abbott Laboratories, Abbot Park, IL, USA) and the Elecsys NT-proBNP test (Roche Diagnositics), respectively.

    Embedded ImageDiagnostic standard:

    blinded …

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    Footnotes

    • For correspondence: Dr M Haltmayer, Konventhospital Barmherzige Brueder, Linz, Austria. Meinhard.haltmayerbblinz.at

    • Source of funding: in part, Upper Austrian Government.