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Q In Danish children, are perinatal factors and parental psychiatric history and social economic status associated with subsequent development of autism?
Clinical impact ratings GP/FP/Mental Health ★★★★★☆☆ Paediatrics ★★★★★★☆ Psychiatry ★★★★★★★
METHODS
Design:
a case control study nested within a cohort of all children born in Denmark after 1972.
Setting:
Denmark
Patients:
698 children (76% boys, mean age at diagnosis 7.7 y) who were discharged from a Danish psychiatric hospital with a diagnosis of infantile or atypical autism before the end of December 1999 constituted the cases. For each case, 25 controls (total n = 17 450) were identified and individually matched to the cases by sex, birth year, and age in days.
Risk factors:
perinatal risk factors including delivery and newborn characteristics (eg, fetal …
Footnotes
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For correspondence: Dr W W Eaton, Johns Hopkins University, Baltimore, MD, USA. weaton{at}jhsph.edu
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Sources of funding: Centers for Disease Control and Prevention; March of Dimes Birth Defects Foundation; Stanley Medical Research Institute; National Institute of Mental Health.