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Review: viscosupplementation for knee osteoarthritis reduces pain and improves function

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 Q In patients with osteoarthritis of the knee, does viscosupplementation (with hyaluronan or hylan [HA]) relieve pain and improve physical function?

Clinical impact ratings Rheumatology ★★★★★☆☆ Physical medicine & rehabilitation ★★★★★★☆

METHODS

Embedded ImageData sources:

Medline, EMBASE/Excerpta Medica, PREMEDLINE (to July 2003), Cochrane Central Register of Controlled Trials (Issue 2, 2003), and Current Contents (to September 2000); handsearches of relevant journals, conference proceedings (to April 2004), and reference lists; and consultation with industry representatives.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs), in any language, that assessed the use of viscosupplementation for treatment of osteoarthritis of the knee, compared with placebo or active treatment, and reported relevant outcomes. 2 reviewers independently assessed included trials for methodological quality using the Jadad scale.

Embedded ImageOutcomes:

pain and physical function (assessed by the Western …

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