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First line treatment with colchicine reduced recurrent pericarditis

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 Q In patients with recurrent pericarditis, does the addition of colchicine to conventional therapy with aspirin or prednisone reduce recurrence better than conventional therapy alone?

Clinical impact ratings IM/Ambulatory care ★★★★★☆☆ Internal medicine ★★★★★☆☆ Cardiology ★★★★★☆☆

METHODS

Embedded ImageDesign

randomised controlled trial (COlchicine for REcurrent pericarditis [CORE] trial).

Embedded ImageAllocation

{concealed*}†.

Embedded ImageBlinding

blinded {data collectors, outcome assessors, monitoring committee, and data analysts}†.*

Embedded ImageFollow up period

mean 20 months (range 8–44 mo).

Embedded ImageSetting

a hospital in Torino, Italy.

Embedded ImagePatients

84 patients ⩾18 years of age (mean age 54 y, 65% women) who had a first recurrence of pericarditis and previous idiopathic, viral, and autoimmune causes of the first episode of acute pericarditis. Exclusion criteria were tuberculous, neoplastic, or purulent causes of the first episode; severe liver disease or transaminase concentrations >1.5 times the upper limit of …

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