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Therapeutics
Review: long term anticoagulation reduces recurrent venous thromboembolism

https://doi.org/10.1136/ebm.11.2.45

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    Ost D, Tepper J, Mihara H, et al. Duration of anticoagulation following venous thromboembolism: a meta-analysis. JAMA 2005;294:706–15.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 Q In patients with venous thromboembolism (VTE), does long term anticoagulation reduce recurrence?

    Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★★☆ Respirology ★★★★★★☆ Haematology ★★★★★★☆

    METHODS

    Embedded ImageData sources

    PubMed, EMBASE/Excerpta Medica Pharmacology, the Cochrane Central Register of Controlled Trials, clinical trial Web sites of the US government (www.clinicaltrials.gov), and GlaxoSmithKline (http://ctr.glaxowellcome.co.uk) (1969–2004).

    Embedded ImageStudy selection and assessment

    randomised controlled trials (RCTs) that compared different durations of anticoagulation in patients with VTE, in which initial therapy was similar in both study groups after diagnosis, and recurrent VTE was assessed. Studies that enrolled only high risk patients (such as protein S or C deficiency) were excluded. Study quality was assessed using the 5 point Jadad scale and a quality scale specific for VTE.

    Embedded ImageOutcomes

    incidence rates of recurrent VTE and major bleeding.

    MAIN RESULTS

    Analysis was based on a hypothetical model with 4 time points: At time A, …

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    Footnotes

    • For correspondence: Dr D Ost, North Shore University Hospital, Manhasset, NY, USA. dost{at}nshs.edu

    • Source of funding: not stated.