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The 5 component acellular pertussis vaccine combined with tetanus and diphtheria toxoids was efficacious in adolescents and adults

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 Q In adolescents and adults, is a 5 component acellular pertussis vaccine combined with tetanus and diphtheria toxoids (Tdap) as immunogenic and as safe as the licensed tetanus and diphtheria toxoid (Td) vaccine?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Internal medicine ★★★★★☆☆ Infectious disease ★★★★★★☆

METHODS

Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:

concealed.

Embedded ImageBlinding:

blinded (patients, healthcare providers, outcome assessors, and laboratory personnel).

Embedded ImageFollow up period:

28 days for immunogenicity and 6 months for safety.

Embedded ImageSetting:

39 clinical centres in the US.

Embedded ImageParticipants:

4480 healthy adolescents and adults with body temperature <38.0°C. Exclusion criteria included receipt of any pertussis, diphtheria, or tetanus containing vaccines in the past 5 years; diagnosis of pertussis within 2 years; allergy or sensitivity …

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