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Q In postmenopausal women with prior hysterectomy, does conjugated equine oestrogen (CEE) improve health related quality of life (HRQOL)?
Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Gynaecology ★★★★★★☆ Endocrine ★★★★★☆☆
METHODS
Design:
randomised placebo controlled trial (Women’s Health Initiative [WHI]).
Allocation:
{concealed*}†.
Blinding:
blinded (patients, healthcare providers, {data collectors, and outcome assessors}†).*
Follow up period:
1 year.
Setting:
{40 US clinical centres}‡.
Patients:
10 739 postmenopausal women aged 50–79 years (mean age 64 y, 75% white) with prior hysterectomy. Exclusion criteria included probable survival <3 years and breast cancer. 17% of women had moderate to severe vasomotor symptoms.
Intervention:
oral CEE 0.625 mg/day (n = 5310) or placebo (n = 5429).
Outcomes:
HRQOL (RAND36, 36 items, 8 subscales, range for each subscale …
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