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Long term fenofibrate did not reduce major coronary events but may reduce total CVD events in type 2 diabetes

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 Q In patients with type 2 diabetes mellitus, what is the effect of long term fenofibrate therapy on coronary heart disease (CHD) events?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Geriatrics ★★★★★☆☆

METHODS

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randomised placebo-controlled trial (Fenofibrate Intervention and Event Lowering in Diabetes [FIELD]).

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concealed.*

Embedded ImageBlinding

blinded (clinicians, patients, and outcome assessors).*

Embedded ImageFollow up period

median 5 years.

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63 centres in Australia, New Zealand, and Finland.

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9795 patients 50–75 years of age (mean age 62 y, 63% men) who had a World Health Organization diagnosis of type 2 diabetes, total cholesterol concentration 3–6.5 mmol/l, and a total cholesterol/high density lipoprotein (HDL) cholesterol ratio ⩾4 or a triglyceride concentration of 1–5 mmol/l, with no clear indication for lipid modifying therapy. Exclusion criteria were renal impairment, chronic liver disease, symptomatic gallbladder disease, or occurrence of a cardiovascular disease (CVD) event within 3 months …

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