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Clopidogrel plus aspirin was inferior to oral anticoagulation for preventing vascular events in atrial fibrillation

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 Q In patients with atrial fibrillation (AF), is clopidogrel plus aspirin non-inferior to oral anticoagulation for preventing vascular events?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Cardiology ★★★★★★☆ Haematology ★★★★★★★

METHODS

Embedded ImageDesign:

randomised controlled trial (Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events [ACTIVE W]).

Embedded ImageAllocation:

concealed.*

Embedded ImageBlinding:

blinded (outcome assessors and monitoring committee).*

Embedded ImageFollow up period:

median 1.28 years.

Embedded ImageSetting:

30 clinical centres worldwide.

Embedded ImagePatients:

6706 patients (mean age 70 y, 66% men) with AF and ⩾1 of the following criteria: age ⩾75 years; receiving treatment for systemic hypertension; previous stroke, transient ischaemic attack, or non-central nervous system (non-CNS) systemic embolus; left ventricular dysfunction with left ventricular ejection fraction <45%; peripheral arterial disease; or age 55–74 years with diabetes mellitus requiring drug therapy …

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