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Esomeprazole did not universally improve asthma outcomes in moderate to severe stable asthma

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 Q In patients with moderate to severe stable asthma, does treatment with esomeprazole improve asthma outcomes?

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★★☆☆ Gastroenterology ★★★★★★☆ Respirology ★★★★★☆☆

METHODS

Embedded ImageDesign:

randomised, placebo controlled trial.

Embedded ImageAllocation:

{concealed*}.

Embedded ImageBlinding:

blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, monitoring committee, and manuscript writers}.*

Embedded ImageFollow up period:

16 weeks.

Embedded ImageSetting:

122 centres in North and South America and Europe.

Embedded ImagePatients:

770 patients 18–70 years of age (mean age 45 y, 70% women) with stable, adequately treated asthma, FEV1 50–80% of predicted with ⩾12% reversibility, and mean morning peak expiratory flow (PEF) <80% predicted. Exclusion criteria included recent use of a proton pump inhibitor and recurrent moderate to severe symptoms of gastro-oesophageal reflux disease (GORD) in patients >40 years of age. During …

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