Article Text

PDF
Diuretics were superior to calcium channel blockers and short term ACE inhibitors for reducing heart failure in hypertension

Statistics from Altmetric.com


 
 Q In high risk patients with hypertension, what is the effect of chlorthalidone, amlodipine, and lisinopril on hospitalised or fatal heart failure (HF)? Does the effect differ across time and prespecified subgroups?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★★ Cardiology ★★★★★★☆

METHODS

Embedded ImageDesign:

randomised controlled trial (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial [ALLHAT]).

Embedded ImageAllocation:

{concealed*}.

Embedded ImageBlinding:

blinded {patients, clinicians, data collectors, outcome assessors, and investigators}.*

Embedded ImageFollow-up period:

mean 4.9 years.

Embedded ImageSetting

{623 centers in the US, Canada, Puerto Rico, and the US Virgin Islands.}

Embedded ImagePatients

33 357 patients who were ⩾55 years of age (mean age 67 y, 53% men) and had stage 1 or 2 hypertension plus an additional risk factor for coronary artery disease. Exclusion criteria were history of hospitalised or symptomatic HF or known left ventricular …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Glossary
    BMJ Publishing Group Ltd
  • Other articles noted
    BMJ Publishing Group Ltd