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Atorvastatin at 80 mg/day reduced cerebrovascular events more than atorvastatin at 10 mg/day in stable coronary heart disease

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 Q In patients with stable coronary heart disease (CHD), is intensive atorvastatin therapy more effective than moderate atorvastatin therapy for reducing cerebrovascular events?

Clinical impact ratings IM/Ambulatory care ★★★★★★☆ Cardiology ★★★★★★☆ Neurology ★★★★★★☆ Endocrine ★★★★★★☆

METHODS

Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:

{concealed*}.

Embedded ImageBlinding:

blinded (clinicians, patients, and endpoints adjudication committee).*

Embedded ImageFollow up period:

median 4.9 years.

Embedded ImageSetting:

256 sites in 14 countries across 4 continents.

Embedded ImagePatients:

10 001 patients 35–75 years of age (mean age 61 y, 81% men) who had clinically evident CHD (defined as previous myocardial infarction or coronary revascularisation, or previous or current angina with objective evidence of CHD), low density lipoprotein cholesterol (LDL-C) concentration 130–250mg/dl (3.4–6.5 mmol/l), and triglyceride concentration ⩽600 mg/dl (6.8 mmol/l). LDL-C concentration was required to be <130 mg/dl (3.4 mmol/l) during an 8 week run in period with atorvastatin, 10 mg/day.

Embedded ImageIntervention:

atorvastatin, 80 mg/day (n = 4995) …

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