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Review: pioglitazone does not reduce risk of mortality or cardiovascular events in type 2 diabetes

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 Q In patients with type 2 diabetes, does pioglitazone reduce cardiovascular events, other adverse events, and mortality or improve health related quality of life?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Cardiology ★★★★★★☆ Endocrine ★★★★★★☆

METHODS

Embedded ImageData sources:

Cochrane Library (issue 3, 2006), Medline, EMBASE/Excerpta Medica (to August 2006), Controlled Clinical Trials, and reference lists.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) ⩾24 weeks in duration that evaluated pioglitazone in adults with type 2 diabetes. 22 RCTs (n = 12 466, mean age range 54–64 y) met the selection criteria: pioglitazone v placebo (4 RCTs) or another oral antidiabetic medication (13 RCTs), or pioglitazone combined with other oral medications or insulin v another combination of oral medications or insulin (7 RCTs). Assessment of methodological quality included randomisation method, allocation concealment, blinding, intention to treat analysis, and …

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