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Q In patients with transient ischaemic attack (TIA), how does a new unified risk score (ABCD2) compare with the previously developed ABCD and California scores for predicting 2, 7, and 90 day stroke risk?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Neurology ★★★★★★☆ Internal medicine ★★★★★☆☆
METHODS
Design:
6 cohort studies: 2 derivation cohorts (California emergency department [ED] and Oxford population) and 4 independent validation cohorts (California ED, California clinic, Oxford population, and Oxford clinic).
Setting:
EDs and primary care clinics in the San Francisco Bay area, California, USA and family practices and specialist clinics in Oxfordshire, UK.
Patients:
1916 patients (78% >60 y, 52% women) for derivation and 2893 patients (76% >60 y, 53% women) for validation who were diagnosed with TIA by the initial treating doctor.
Description of prediction guide:
The ABCD2 score was generated in the 2 original derivation cohorts by multivariate logistic regression analysis of individual risk factors from the ABCD and California scores. The risk score …