Article Text

PDF
Carvedilol was more effective than metoprolol for preventing cardiovascular events in heart failure

Statistics from Altmetric.com


 
 Q In patients with heart failure (HF), what is the relative effectiveness of carvedilol and metoprolol for preventing cardiovascular events?

Clinical impact ratings Internal medicine ★★★★★★☆ Cardiology ★★★★★★☆

METHODS

Embedded ImageDesign:

randomised controlled trial (Carvedilol Or Metoprolol European Trial [COMET]).

Embedded ImageAllocation:

{concealed}*.

Embedded ImageBlinding:

blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, and monitoring committee}*.

Embedded ImageFollow up period:

mean 58 months.

Embedded ImageSetting:

{341 centres in 15 European countries}*.

Embedded ImagePatients:

3029 patients (mean age 62 y, 80% men) with stable chronic HF, left ventricular ejection fraction ⩽35%, and ⩾1 cardiovascular hospital admission in the previous year, who were being treated with an angiotensin converting enzyme inhibitor and diuretics. Exclusion criteria included important valvular disease or ventricular …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles