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Q In patients with heart failure (HF), what is the relative effectiveness of carvedilol and metoprolol for preventing cardiovascular events?
Clinical impact ratings Internal medicine ★★★★★★☆ Cardiology ★★★★★★☆
METHODS
Design:
randomised controlled trial (Carvedilol Or Metoprolol European Trial [COMET]).
Allocation:
{concealed}*.†
Blinding:
blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, and monitoring committee}*.†
Follow up period:
mean 58 months.
Setting:
{341 centres in 15 European countries}*.
Patients:
3029 patients (mean age 62 y, 80% men) with stable chronic HF, left ventricular ejection fraction ⩽35%, and ⩾1 cardiovascular hospital admission in the previous year, who were being treated with an angiotensin converting enzyme inhibitor and diuretics. Exclusion criteria included important valvular disease or ventricular …
Footnotes
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For correspondence: Dr W J Remme, Sticares Cardiovascular Research Foundation, Rhoon, The Netherlands. w.j.remme{at}sticares.org
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Sources of funding: F. Hoffmann-La Roche and GlaxoSmithKline.