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10 day sequential therapy was more effective than 10 day triple drug therapy for eradicating Helicobacter pylori infection

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 Q In patients with dyspepsia or peptic ulcer disease, is 10 day sequential therapy more effective than 10 day triple drug therapy for eradicating Helicobacter pylori infection?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Gastroenterology ★★★★★★☆ IM/Ambulatory care ★★★★★★☆

METHODS

Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:

{concealed}*.

Embedded ImageBlinding:

blinded (patients, investigators, {data collectors, outcome assessors, data analysts, and data safety and monitoring committee}*).

Embedded ImageFollow-up period:

8 weeks.

Embedded ImageSetting:

2 hospitals in Bologna and Rome, Italy.

Embedded ImagePatients:

300 patients ⩾18 years of age (mean age 49 y, 64% women) with dyspepsia or peptic ulcers who had never received treatment for H Pylori infection. Exclusion criteria included use of proton pump inhibitors, H2 receptor antagonists, bismuth preparations, or antibiotics in the past 2 weeks; concomitant use of anticoagulants or ketoconazole and glucocorticoids; Zollinger Ellison syndrome; …

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