METHODS

Design:

2 cohort studies, 1 for derivation and 1 for validation.

Setting:

endoscopy department at the Royal Hallamshire Hospital, Sheffield, UK.

Patients:

1464 patients in the retrospective derivation cohort and 2000 patients 16–94 years of age (mean age 56 y, 58% women) in the prospective validation cohort who were referred for gastroscopy. Exclusion criteria were previously known coeliac disease, coagulopathy (international normalised ratio >1.3 or platelets <80 x 10⁹/l), active gastrointestinal bleeding, or suspected cancer.

Description of prediction guide:

the CDT combined pre-endoscopic serological testing (tissue transglutaminase [TTG] antibody) and assessment of symptoms to identify patients at high or low risk of coeliac disease. The CDT was modified in the validation …