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Symptomatic use of beclomethasone-albuterol and regular use of beclomethasone did not differ for control of mild asthma

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In patients with mild, persistent asthma, is symptomatic use of beclomethasone-albuterol in combination as effective as regular use of the same dose of beclomethasone and superior to symptomatic use of albuterol for controlling asthma?

Papi A, Canonica GW, Maestrelli P, et al. Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma. N Engl J Med 2007;356:2040–52.

Clinical impact ratings Internal medicine ★★★★★★★ Respirology ★★★★★★★ Allergy & immunology ★★★★★★⋆

METHODS

Embedded ImageDesign:

randomised controlled trial (Beclomethasone plus Salbutamol Treatment [BEST] study).

Embedded ImageAllocation:

unclear allocation concealment.*

Embedded ImageBlinding:

blinded (unclear).*

Embedded ImageFollow-up period:

6 months.

Embedded ImageSetting:

25 centres in Italy, Austria, Poland, and Spain.

Embedded ImagePatients:

466 patients, 18–65 years of age, with mild, persistent asthma for ⩾6 months, prebronchodilator FEV1 ⩾75% of predicted value, and controlled asthma during …

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