Article Text

PDF
Review: on-demand maintenance therapy with proton pump inhibitors is as effective as continuous therapy for non-erosive GORD

Statistics from Altmetric.com

In patients with gastro-oesophageal reflux disease (GORD), is on-demand maintenance therapy with proton pump inhibitors (PPIs) effective for controlling symptoms and preventing relapse?

Pace F, Tonini M, Pallotta S, et al. Systematic review: maintenance treatment of gastro-oesophageal reflux disease with proton pump inhibitors taken ‘on-demand.’ Aliment Pharmacol Ther 2007;26:195–204.

Clinical impact ratings GP/FP/Primary care ★★★★★★⋆ Internal medicine ★★★★★★⋆ Gastroenterology ★★★★★⋆⋆

METHODS

Embedded ImageData sources:

Medline and Cochrane Controlled Trials Register (to December 2006), and reference lists.

Embedded ImageStudy selection and assessment:

studies published in English as full articles that compared on-demand maintenance therapy, using PPIs or H2-receptor antagonists, with placebo or continuous maintenance therapy in patients with GORD, with or without erosive oesophagitis. 17 articles reporting on 16 studies (n = 14 142) met the selection criteria. All studies used PPIs (esomeprazole, 20 or 40 mg; …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.