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J A DiPalma
Dr J A DiPalma, University of South Alabama Digestive Health Centre, Mobile, AL, USA; firstname.lastname@example.org
randomised placebo-controlled trial.
unclear allocation concealment.*
blinded (not clear who were blinded).*
50 centres in the US.
306 patients with chronic constipation over the past 3 months (<3 satisfactory stools per wk without laxative use, and ⩾1 of the following Rome criteria: straining, lumpy or hard stools, or sensation of incomplete evacuation in >25% of defecations) and during a 14-day observation period (<3 satisfactory bowel movements per wk). Exclusion criteria were prior or current treatment with or sensitivity to study medication; use of medications affecting bowel function; irritable bowel syndrome; pregnancy or …
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