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  • Review: available evidence does not support a benefit for thyroid hormone replacement in adults with subclinical hypothyroidism

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Therapeutics
Review: available evidence does not support a benefit for thyroid hormone replacement in adults with subclinical hypothyroidism

https://doi.org/10.1136/ebm.13.1.22

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    H Villar

    Dr H Villar, Faculdade Estadual de Medicina de Marília, São Paulo, Brazil; hvillar@famema.br

    REVIEW PROCESS

    Aim:

    in adults with subclinical hypothyroidism, what is the effect of thyroid hormone replacement on cardiovascular mortality and morbidity, symptoms, and quality of life?

    Search methods:

    Medline, EMBASE/Excerpta Medica, CINAHL, and LILACS to May 2006; Cochrane Library (2006, Issue 1); Current Controlled Trials; references of relevant studies and systematic reviews; experts; and pharmaceutical companies.

    Study selection and assessment:

    randomised controlled trials (RCTs) that compared thyroid hormone replacement therapy (triiodothyronine [T3], thyroxine [T4], or both) with placebo or no treatment in adult outpatients with subclinical hypothyroidism and no severe illness. Treatment was given for ⩾1 month with ⩾3 months follow-up. Subclinical hypothyroidism was defined as a thyroid-stimulating hormone (TSH) concentration > upper limit of the test reference value. 12 RCTs (n = 485, >75% women) met the selection criteria; all compared …

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    Footnotes

    • Source of funding: not stated.