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N-terminal pro-B-type natriuretic peptide concentrations ⩾100 ng/l increased risk of all-cause mortality

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W März

Dr W März, Synlab Center of Laboratory Diagnostics, Heidelberg, Germany; maerz@synlab.de

STUDY QUESTION

In patients with or without stable coronary artery disease (CAD), what is the relation between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and risk of cardiovascular (CV) and all-cause mortality?

STUDY DESIGN

Design:

prospective hospital-based cohort study (The Ludwigshafen Risk and Cardiovascular Health Study).

Setting:

Ludwigshafen General Hospital, Ludwigshafen, Germany.

Patients:

1641 patients (mean age 61 y, 69% men) who had coronary angiography but did not have major non-CV disease; 1135 patients had stable CAD and 506 did not have stable CAD. Exclusion criteria were unstable angina, ST-segment elevation myocardial infarction (STEMI), non-STEMI, or valve disease.

Risk factors:

NT-proBNP concentrations (100–399 ng/l, 400–1999 ng/l, and …

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