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Review: vitamin D supplementation decreases all-cause mortality in adults and older people

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P Autier

Dr P Autier, International Agency for Research on Cancer, Lyon, France; autierp@iacr.fr

REVIEW PROCESS

Question:

what is the effect of vitamin D supplementation on all-cause mortality?

Search methods:

PubMed, ISI Web of Science (Science Citation Index Expanded), EMBASE/Excerpta Medica, Cochrane Library, and bibliographies of selected studies, reviews, or books (to November 2006).

Study selection and assessment:

principal published reports of randomised controlled trials (RCTs) that assessed the effects of vitamin D supplementation (vitamin D2 [ergocalciferol] or vitamin D3 [cholecalciferol]), taken for any condition, on all-cause mortality. Trials had to randomise participants on an individual (rather than cluster) basis and include sufficient information to allow for calculation of relative risks and 95% CIs for all-cause mortality for vitamin D supplementation v placebo or control. …

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