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Review: β-blockers for hypertension increase risk of new onset diabetes

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S Bangalore

Dr S Bangalore, Columbia University College of Physicians and Surgeons, New York, NY, USA; sbangalo@chpnet.org

REVIEW PROCESS

Question:

in patients with hypertension, do β-blockers increase risk of new onset diabetes?

Search methods:

Medline, PubMed, and EMBASE/Excerpta Medica (to March 2007).

Study selection and assessment:

randomised controlled trials (RCTs) that were published in English in peer-reviewed journals, compared β-blockers with placebo or other antihypertensive agents as first line therapy for hypertension, and reported incidence of new onset diabetes at ⩾1 year. 12 RCTs (n = 94 492, mean age 50–76 y, 33–100% men) met the selection criteria: 2 RCTs (n = 16 372) compared β-blockers with placebo, 5 RCTs (n = 17 860) compared β-blockers with thiazide diuretics, and 7 RCTs (n = 65 765) compared β-blockers (with or without diuretics) with non-diuretic antihypertensive agents (angiotensin converting enzyme [ACE] inhibitors, angiotensin receptor blockers [ARBs], or calcium …

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