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Dr C Crowther
Correspondence to: Dr C Crowther, University of Adelaide, Adelaide, South Australia, Australia; caroline.crowther@adelaide.edu.au
QUESTION
In women at risk of preterm birth, what is the effectiveness and safety of multiple doses of antenatal corticosteroids (ACSs) compared with a single dose for preventing neonatal respiratory disease?
REVIEW SCOPE
Studies comparing repeat dose(s) of ACSs with placebo or no treatment for preventing neonatal morbidity in women still at risk of preterm delivery ⩾7 days after a first dose were selected. Outcomes were respiratory distress syndrome, severe lung disease, serious infant morbidity, birthweight, perinatal mortality, and maternal morbidity.
REVIEW METHODS
Cochrane Pregnancy and Childbirth Group’s trials register (February 2007); Cochrane Central Register of Controlled Trials, Medline, EMBASE/Excerpta Medica, and Current Contents (to November 2006); reference lists; and abstracts of major congresses were searched for randomised controlled trials (RCTs). Experts …
Footnotes
Source of funding: Australian Department of Health and Aging.