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Review: multiple doses of antenatal corticosteroids prevent preterm neonatal respiratory disease more than a single dose

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Dr C Crowther

Correspondence to: Dr C Crowther, University of Adelaide, Adelaide, South Australia, Australia; caroline.crowther@adelaide.edu.au

QUESTION

In women at risk of preterm birth, what is the effectiveness and safety of multiple doses of antenatal corticosteroids (ACSs) compared with a single dose for preventing neonatal respiratory disease?

REVIEW SCOPE

Studies comparing repeat dose(s) of ACSs with placebo or no treatment for preventing neonatal morbidity in women still at risk of preterm delivery ⩾7 days after a first dose were selected. Outcomes were respiratory distress syndrome, severe lung disease, serious infant morbidity, birthweight, perinatal mortality, and maternal morbidity.

REVIEW METHODS

Cochrane Pregnancy and Childbirth Group’s trials register (February 2007); Cochrane Central Register of Controlled Trials, Medline, EMBASE/Excerpta Medica, and Current Contents (to November 2006); reference lists; and abstracts of major congresses were searched for randomised controlled trials (RCTs). Experts …

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