Article Text

PDF
Review: misoprostol and intramuscular prostaglandins do not prevent postpartum haemorrhage more than injectable uterotonics

Statistics from Altmetric.com

Dr A M Gülmezoglu

Correspondence to: Dr A M Gülmezoglu, World Health Organization, Geneva, Switzerland; gulmezoglum@who.int

QUESTION

How effective are prophylactic prostaglandins in preventing postpartum haemorrhage (PPH)?

REVIEW SCOPE

Selected studies compared a prostaglandin with no uterotonic agent, placebo, or another uterotonic agent as part of the routine management of the third stage of labour. Outcomes were severe PPH (blood loss ⩾1000 ml), need for blood transfusion, use of additional uterotonics, and adverse effects.

REVIEW METHODS

Cochrane Pregnancy and Childbirth Group’s trials register (February 2007) and PubMed (July 2006) were searched for randomised controlled trials (RCTs). 46 RCTs (n = 42 621) were included; 32 used adequate allocation concealment.

MAIN RESULTS

The table shows results for oral misoprostol. Rectal misoprostol …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.