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Altering the glycaemic index or carbohydrate intake did not affect glycaemic control in type 2 diabetes

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T M Wolever

Dr T M Wolever, University of Toronto, Toronto, Ontario, Canada; Thomas.wolever@utoronto.ca

STUDY DESIGN

Design:

randomised controlled trial.

Allocation:

concealed.*

Blinding:

unblinded.*

STUDY QUESTION

Setting:

5 hospitals in Canada.

Patients:

162 patients 35–75 years of age (mean age 60 y, 54% women) with type 2 diabetes managed by diet alone, haemoglobin (Hb) A1c ⩽130% of the upper limit of normal, and body mass index 24–40 (mean 31) kg/m2. Exclusion criteria included pregnancy; recent stroke, myocardial infarction, or major surgery; and serum triacylglycerol concentration >10 mmol/l.

Interventions:

high-carbohydrate (CHO) and high-glycaemic index (GI) diet (high-GI diet, n = 52); high-CHO and low-GI diet (low-GI diet, n = 56); or low-CHO and high-monounsaturated fatty acids (MUFA) diet (low-CHO diet, n = 54) for 1 year with regular visits with a dietician who provided individualised advice and support.

Outcomes:

HbA1c, plasma glucose, blood lipids, and …

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