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Review: paroxetine and placebo do not differ for treatment discontinuation in major depression

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C Barbui

Dr C Barbui, University of Verona, Verona, Italy; corrado.barbui@univr.it

QUESTION

In participants with major depression, what is the effectiveness and acceptability of paroxetine?

REVIEW SCOPE

Included studies compared any flexible- or fixed-dose (⩾20 mg/d) regimen of any pharmaceutical form of paroxetine with placebo in participants ⩾18 years of age with major depression. Outcomes included treatment discontinuation, depression, <50% improvement in symptoms, adverse events, and suicidal tendencies.

REVIEW METHODS

Medline; EMBASE/Excerpta Medica; Cochrane Collaboration Depression, Anxiety, and Neurosis Controlled Trials Register; Cochrane Central Register of Controlled Trials; and Glaxo-SmithKline Clinical Trial Register (all to December 2006) were searched for published and unpublished randomised placebo controlled trials (RCTs). 29 published RCTs and 11 unpublished RCTs (n = 6391) were included in …

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