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Review: reduction in resting heart rate after taking β-blockers or calcium-channel blockers reduce mortality and morbidity after MI

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M Cucherat

Dr M Cucherat, Universite Lyon, Lyon, France; mcu@upcl.univ-lyon.fr

QUESTION

In patients who have had a myocardial infarction (MI), do reductions in resting heart rate (HR) after treatment with β-blockers (BBs) or calcium-channel blockers (CCBs) reduce mortality and morbidity?

REVIEW SCOPE:

Included studies evaluated BBs or CCBs in patients with a history of MI followed for ⩾1 year with <10% attrition. Outcomes were relation between resting HR reduction and all-cause mortality, cardiac death, cardiovascular (CV) death, sudden death, non-fatal MI recurrence, fatal and non-fatal MI, and cardiac events.

REVIEW METHODS:

Medline and EMBASE (1966 to January 2006), Cochrane Controlled Trials Register (Issue 4, 2005), reference lists, and conference proceedings were searched for randomised, double-blind, placebo controlled trials (RCTs). 25 RCTs (n = 30 904; mean age range 48-81 y based on 14 RCTs) met …

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