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A rapid antibody test had high specificity but low sensitivity for diagnosing coeliac disease

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M Maki

Dr M Maki, Tampere University Hospital and Medical School, Tampere, Finland; markku.maki@uta.fi

STUDY QUESTION

Is a rapid antibody test accurate for diagnosing coeliac disease in children?

STUDY DESIGN

Design:

blinded comparison of a rapid IgA antibody test with combined IgA plus IgG antibody test and small bowel biopsy.

Setting:

Jász-Nagykun-Szolnok county, Hungary.

Patients:

2690 children, 6 years of age, who had a preschool physical examination.

Description of tests:

the rapid antibody test detected IgA antibodies to tissue transglutaminase in whole blood from a finger prick (evaluated after 5 min). The combined antibody test detected IgA and IgG antibodies to endomysium and IgA antibodies to tissue transglutaminase from capillary blood.

Diagnostic standard:

biopsy samples of the small intestine were taken during upper gastrointestinal endoscopy from …

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