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Review: little high-quality evidence is available regarding treatments for localised prostate cancer

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T J Wilt

Dr T J Wilt, University of Minnesota School of Medicine, Minneapolis, MN, USA; tim.wilt@med.va.gov

QUESTION

In men with localised prostate cancer, what is the evidence for effectiveness and harm of various treatments?

REVIEW SCOPE

Included studies evaluated treatments for localised prostate cancer (tumour stage T1 or T2). Outcomes were all-cause and disease-related mortality, biochemical and clinical progression, and adverse events.

REVIEW METHODS

Cochrane Library (Issue 3, 2007) and Cochrane Review Group in Prostate Diseases and Urologic Malignancies specialised register (Nov 2007) were searched for randomised controlled trials (RCTs). Other sources were searched for observational studies. 18 RCTs (n = 6482, mean age 63–73 y, mean follow-up 3–23 y), 1 pooled analysis of 3 RCTs (n = 8113, mean age 67 y, median follow-up 5.4 y), …

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