Article Text

PDF
Review: limited evidence suggests that statins are safe in patients with liver disease

Statistics from Altmetric.com

M D Onofrei

Dr M D Onofrei, Providence Physician Division, Milwaukie, OR, USA; mihai.onofrei@providence.org

QUESTION

Is statin therapy safe in patients with pre-existing liver disease?

REVIEW SCOPE

Included studies evaluated the safety of statins available in the USA in patients with pre-existing liver disease. Outcomes were elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) concentrations or liver function tests, and survival.

REVIEW METHODS

Medline (Jun 2007), abstracts from major medical meetings, and references were searched for clinical trials, meta-analyses, and validation studies in English. 19 studies (n = 1563 receiving statins) met the selection criteria. Duration of follow-up ranged from 1 …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.