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Dr A Patel, University of Sydney, Sydney, New South Wales, Australia; firstname.lastname@example.org
randomised controlled trial (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation [ADVANCE]).
blinded (outcome adjudication committee).*
215 centres in 20 countries in Asia, Australasia, Europe, and North America.
11 140 patients ⩾55 years of age (mean age 66 y, 58% men) who had type 2 diabetes and a history of, or risk factors for, vascular disease. Patients requiring insulin were excluded.
intensive glucose control with gliclazide modified-release, 30–120 mg/d, and other non-sulfonylurea drugs as needed to achieve a target glycated haemoglobin concentration ⩽6.5% (n = 5571) or standard glucose control with drugs other than gliclazide (n = 5569).
composite of macrovascular events (non-fatal myocardial infarction or stroke, or death from cardiovascular causes) and composite of microvascular events (new or worsening nephropathy [including macroalbuminuria] or retinopathy). Secondary outcomes included new-onset microalbuminuria and severe hypoglycaemia.
median 5 years. …
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