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Lifestyle interventions reduced the long-term risk of diabetes in adults with impaired glucose tolerance

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G Li

Dr G Li, China-Japan Friendship Hospital, Beijing, China; guangwei_li@medmail.com.cn

STUDY DESIGN

Design:

cluster randomised controlled trial (China Da Qing Diabetes Prevention Outcomes Study [CDQDPOS]).

Allocation:

unconcealed.*

Blinding:

blinded (data collectors and outcome adjudicators).*

STUDY QUESTION

Setting:

33 clinics in Da Qing, China.

Patients:

577 adults (mean age 46 y, 54% men) with impaired glucose tolerance.

Interventions:

1 of 3 group-based lifestyle interventions for 6 years: diet (to increase vegetable intake, lower alcohol and sugar intake, and reduce weight if indicated), exercise (to increase leisure-time physical activity), or diet plus exercise (n = 438, 3 groups pooled); or usual care (n = 138).

Outcomes:

diabetes, cardiovascular disease (CVD) event (myocardial infarction, stroke, sudden death, or amputation), CVD mortality, and all-cause mortality.

Patient follow-up:

94–98% (intention-to-treat analysis). …

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