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Evid Based Med 13:177 doi:10.1136/ebm.13.6.177
  • Therapeutics

Review: antioxidant supplements do not reduce all-cause mortality in primary or secondary prevention

G Bjelakovic

Dr G Bjelakovic, Copenhagen University Hospital, Copenhagen, Denmark. goranb@junis.ni.ac.yu

QUESTION

Do antioxidant supplements reduce all-cause mortality in primary or secondary prevention?

REVIEW SCOPE

Included studies compared antioxidant supplements (β-carotene, vitamin A, vitamin C, vitamin E, or selenium) with placebo or no intervention in healthy participants (primary prevention) or in patients with any disease (secondary prevention) who were ⩾18 years of age. Studies of patients with acute, infectious, or malignant diseases (except non-melanoma skin cancer), or of children or pregnant women, …