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Review: antiviral prophylaxis in pregnant women reduces recurrence of genital herpes at delivery

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L Hollier

Prof L Hollier, LBJ General Hospital, Houston, TX, USA; lisa.m.hollier@uth.tmc.edu

QUESTION

In pregnant women with genital herpes simplex virus (HSV), does antiviral prophylaxis reduce herpes recurrence at delivery and neonatal HSV transmission?

REVIEW SCOPE

Included studies compared oral antiviral drugs (acyclovir, valacyclovir, and famciclovir) taken during the third trimester with placebo or no treatment for prophylaxis of recurrent genital herpes at delivery in women diagnosed with genital herpes before or during pregnancy. Primary outcome was neonatal herpes. Other outcomes were caesarean delivery because of HSV infection, detection of HSV or recurrence of genital herpes in women at delivery, and side effects.

REVIEW METHODS

Medline (1966 to Feb 2007), EMBASE/Excerpta Medica (1974 to Feb 2007), Cochrane Central Register of Controlled Trials (Cochrane Library, Issue 4, 2006), Cochrane Pregnancy and Childbirth Group’s Trials Register (Jan 2007), …

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