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Early, abrupt weaning did not reduce risk of HIV infection or mortality in breast-fed infants of mothers with HIV

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L Kuhn

Dr L Kuhn, Columbia University, New York, NY, USA; lk24@columbia.edu

STUDY DESIGN

Design:

randomised controlled trial.

Allocation:

{concealed}†.*

Blinding:

unblinded.*

STUDY QUESTION

Setting:

2 antenatal clinics in Lusaka, Zambia.

Patients:

958 women (mean age 26 y) who had HIV, were enrolled during pregnancy and planned to breast feed, accepted treatment with nevirapine, and were still breast feeding 1 month after birth. Exclusion criteria were severe pregnancy complications, past caesarean delivery, or hospital admission for HIV-related conditions.

Intervention:

counselling intervention (n = 481), which encouraged women to breast feed exclusively for 4 months and then cease breast feeding abruptly, or standard care (n = 477), where women were encouraged to breast feed exclusively for 6 months, and then continue as long as they wished, with gradual …

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