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Evid Based Med 2009;14:15 doi:10.1136/ebm.14.1.15
  • Therapeutics

Review: faecal occult blood test screening reduces risk of colorectal cancer mortality

P Hewitson

Dr P Hewitson, University of Oxford, Headington, UK; paul.hewitson@dphpc.ox.ac.uk

QUESTION

Does faecal occult blood test (FOBT) screening reduce colorectal cancer mortality?

REVIEW SCOPE

Included studies evaluated annual or biennial screening for colorectal cancer with guaiac or immunochemical FOBTs. Outcomes included incidence of colorectal cancer, colorectal cancer mortality, and all-cause mortality.

REVIEW METHODS

Medline, CINAHL, EMBASE/Excerpta Medica, Cochrane Library (Issue 1, 2005), PsycINFO, Allied and Complementary Medicine Database, System of Information on Grey Literature in Europe, Healthcare Management Information Consortium, and reference lists were searched from 1989 to February 2006 for randomised controlled trials (RCTs). 4 RCTs (n = 329 642, age 45–80 y) …

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